Nueva legislación europea de patentes
2024-02-29
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In this work was described the creation method of the hermetic granules of the X-emitters on base of 131Cs for using in brachytherapy. The chitosan and modified additives are being used as a sorbent for 131CsCl ions. The maximal sorption of 131CsCl ions was obtained by adding to chitosan solution the potassium ferro (II)cyanide and copper or nickel chlorides. For forming the granules of X-emitters, the radioactive drops through of syringe were serially passed through air layer, solutions of the xylene and alkali sodium. The received granules has been crosslinking with glutaraldehyde solution for it`s forming hardness and hermeticity. The diameters and radioactivity of the granules can be regulated within 0.5±0.05 – 1.0±0.1 mm and (7.4 – 22.2)·107 Bq, respectively.
The chitosan and its derivatives are used widely in nuclear medicine as therapeutic preparations. Chitosan compounds used in the pharmaceutical industry have several advantages because of biodegradable, biocompatible, acceleration of wound healing, reduction of blood cholesterol level and inhibition of tumor cells. The natural polymers chitin and chitosan, belonging to the class of polysaccharides – high-molecular compounds that built from elementary units of links of monosaccharides, that connected by glycosidic bonds. The chemical structure of the chitin is a linear aminopolysaccharide that a consisting of units of N-acetyl-2-amino-2-deoxy-D-glycopyranose. A completely deacetylated product - poly [(1-4) -2-amino-2-deoxy-b-D-glucose] - is called chitosan [1–3]. It is insoluble in aqueous, alkali, organic solvents, while it is soluble in acid solutions when the pH is less than 6.0 [2, 3].
